What are the treatments for ulcerative colitis?

A variety of medicines are available to treat ulcerative colitis (UC).

Types of treatment1

  • Aminosalicylates (contain 5-aminosalicylic acid or 5-ASA) are some of the first-line medications for UC.2 It is thought that they work to decrease the inflammation of the gastrointestinal (GI) tract lining. They are effective in treating mild to moderate UC flares, and they are useful as a maintenance treatment to prevent disease relapses.2 Learn more about DELZICOL and how this 5-ASA can help control the symptoms of mild-to-moderate UC.
  • Corticosteroids suppress the immune system and are used to treat moderate to severe active UC. Your doctor may choose to add a steroid to your treatment during flare-ups. These drugs have long-term side effects, and therefore should not be used as a maintenance medication.1
  • Immunomodulators suppress the immune system's ability to activate long-term inflammation. These medicines are generally reserved for people who do not experience relief with aminosalicylates or steroids.
  • Antibiotics may be used when infections occur (such as abscesses).3
  • Biologic therapies are the newest class of agents for moderate to severe UC. These treatments are administered by injection or infusion. Tumor necrosis factor (TNF) is a chemical produced by our bodies that causes inflammation. Some biologic therapies are considered "anti-TNF" agents because they block TNF-alpha, helping to reduce inflammation.4
  • Surgery is an option for people with severe UC and for those who have not reached remission and relief after trying multiple medications.

While there are effective treatments for UC, they cannot cure it. They can help control the symptoms, but you may still experience flares from time to time.1

That doesn't mean you can't have a fulfilling life with UC. By taking your medication as indicated, and learning other ways to manage your UC, the goal is to help control your symptoms and help manage your condition.

  • Types of UC
  • Back to top
  • What is DELZICOL
  • References

  • 1.
    Crohn’s & Colitis Foundation of America. Crohn’s Disease & Ulcerative Colitis: A Guide for Parents. http://www.ccfa.org/assets/pdfs/a-guide-for-parents-2014.pdf. Accessed October 23, 2015.
  • 2.
    Crohn's & Colitis Foundation of America. Aminosalicylates. http://www.ccfa.org/assets/pdfs/aminosalicylates.pdf. Accessed January 7, 2015.
  • 3.
    Crohn's & Colitis Foundation of America. Antibiotics. http://www.ccfa.org/assets/pdfs/antibiotics.pdf. Accessed January 7, 2015.
  • 4.
    Crohn's & Colitis Foundation of America. Medications: Biologic Therapy. http://www.ccfa.org/medications-biologic-therapy.pdf. Accessed January 7, 2015.
  • See More Important Risk Information


    Who should not take DELZICOL?

    • Do not take DELZICOL if you are allergic to:
      • salicylates, such as aspirin or medications that contain aspirin
      • aminosalicylates
      • any of the ingredients of DELZICOL

    What should I tell my healthcare provider before taking DELZICOL?

    Tell your healthcare provider if you:

    • Have or have had kidney problems
    • Are allergic to sulfasalazine
    • Have or have had heart-related allergic reactions, such as inflammation of the heart muscle (myocarditis) or inflammation of the lining of the heart (pericarditis)
    • Have or have had liver problems
    • Have or have had a stomach blockage
    • Have any other medical conditions

    What are the possible side effects of DELZICOL?

    DELZICOL may cause serious side effects, including:

    • Kidney problems: Your doctor may check to see how your kidneys are working before taking DELZICOL. It is important to complete all blood tests ordered by your doctor.
    • A condition that may be hard to tell apart from a UC flare: Symptoms include cramping, stomachache, bloody diarrhea, and sometimes fever, headache, and rash. If you experience any of these symptoms while on treatment, call your doctor right away. He or she may tell you to stop taking DELZICOL.
    • Hypersensitivity (allergic) reactions: If signs and symptoms of hypersensitivity occur, immediately call your doctor.
    • Liver failure: In patients that have or have had liver disease.
    • Blood Disorders: Elderly patients and patients taking azathioprine or 6-mercaptopurine need to monitor complete blood cell counts and platelet counts while taking DELZICOL.

    The most common side effects of DELZICOL include:

    • Adults: belching, stomachache, constipation, dizziness, runny nose, back pain, rash, upset stomach, and flu symptoms.
    • Children (5 to 17 years of age): inflammation of the nose and pharynx, headache, stomachache, dizziness, inflammation of the sinuses, rash, cough, diarrhea, tiredness, fever, and increased lipase.

    Tell your doctor if you have any side effect that bothers you or does not go away. These are not all the possible side effects of DELZICOL.

    Before starting DELZICOL, tell your doctor about all medications you are taking, including:

    • Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen. Taking these medications with DELZICOL may increase your risk of kidney problems.
    • Azathioprine or 6-mercaptopurine. Taking these medications with DELZICOL may increase your risk of blood disorders.

    What is DELZICOL?

    DELZICOL (mesalamine) delayed-release capsules is a prescription medication approved for the treatment of mildly to moderately active ulcerative colitis (UC) in patients 5 years of age and older and for the maintenance of remission of UC in adults.

    Please see full Prescribing Information for DELZICOL.

    To report a side effect from one of our products, please call the Allergan Drug Safety Department at 1-800-678-1605.


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