What if I take DELZICOL?
- How DELZICOL may help you achieve your treatment goals
For adults, there are 2 goals of UC therapy. The first is to quickly bring symptoms under control. The second is to prevent (or delay) flares from coming back.1,2
An important part of successful DELZICOL therapy is taking your medication exactly how your doctor has prescribed. If you are prescribed DELZICOL, you take the capsules a few times a day; this will help ensure that mesalamine is being delivered throughout the day to continue to help soothe the inflammation in your colon.
Other things to keep in mind when taking DELZICOL:
- DELZICOL can be taken with or without food.
- The recommended adult dosage for mildly to moderately active disease, or during a flare, is 2 DELZICOL delayed-release capsules 3 times a day for adults (a total of 6 capsules or 2.4 grams per day) for a duration of 6 weeks.3
- The recommended dosage of DELZICOL delayed-release capsules in adults for remission is a total of 1.6 grams or 4 capsules daily, in divided doses.3
Note that these are recommended doses only. Your doctor will determine the dose that is best for you. If your symptoms remain under control, your doctor may adjust the number of capsules you have to take each day. Remember to always take the medication as your doctor has recommended.
- DELZICOL may help you achieve and stay in remission
Remember, UC has no cure, but DELZICOL can help control your symptoms during periods when your UC is active.4
This section will provide results of important DELZICOL adult clinical trials.
Achieving symptom improvement or remission
In Study 1, nearly half (49%) of patients on DELZICOL (6 capsules daily) experienced improvement or remission at 6 weeks versus 23% of those receiving a placebo. Some patients in this study experienced symptom improvement or were in remission as early as the third week.4
- This study included 158 people with mildly to moderately active UC.
- "Remission" meant complete remission of all symptoms, with assessment scores determined to be zero.
- “Symptom improvement” meant a physician’s measurement showed the patient had improved, plus showed a decrease in rectal bleeding, stool frequency, or inflammation in their colon.
Achieving treatment success
In Study 2, over half (51%) of the patients on DELZICOL had achieved treatment success at 6 weeks, with some achieving it as early as the third week.5
- This study included 150 people with mildly to moderately active UC who were taking 2.4 grams (or 6 DELZICOL capsules) per day.
- "Treatment success" meant that patients either achieved complete remission of their rectal bleeding and stool frequency (among other clinical assessments) by 3 and 6 weeks, or they saw partial improvement in at least one clinical assessment and no worsening of the others.
Time to symptom improvement
In Study 2, over 60% of patients on DELZICOL saw improvement of rectal bleeding and stool frequency by 6 weeks, with some experiencing improvement as soon as 3 weeks.5
- In this trial, "improvement" from baseline could mean either partial response or a complete resolution of symptoms.5
In this same study, the median time to symptom resolution of rectal bleeding was 9 days, and 11 days for total resolution of stool frequency.5
- "Time to symptom resolution" meant how long it took for complete resolution of the symptom from the first day of taking the medicine to the first day of symptom relief.5
Maintenance of remission
Most patients who stayed on treatment with DELZICOL stayed in remission.
In a third clinical study lasting 6 months, 70% of people on DELZICOL maintenance therapy finished the study in remission, versus 48% of those taking a placebo.6
- Study 3 included 264 patients with UC who were in remission at the beginning of the study.
- These patients took 1.6 grams per day of DELZICOL, meaning 4 capsules per day taken in divided doses.
- "Remission" meant that there was no inflammation in the patient’s colon at the beginning of the study and 6 months later, as indicated by diagnostic evaluation.