What is ulcerative colitis?

The gastrointestinal tract is responsible for digesting food, absorbing nutrients, and expelling waste. Ulcerative colitis (UC) is a chronic disease that affects a portion of the gastrointestinal tract known as the large intestine (also called the colon). If you have UC, you're not alone—it's estimated that UC may affect as many as 900,000 people in the U.S.

In UC, the body's immune system can mistakenly target usually harmless substances in the large intestine, such as food and bacteria. This causes the release of various white blood cells into the large intestine, leading to chronic inflammation of the intestine's lining (mucosa).

Over time, inflammation can damage the intestinal lining and ulcers begin to form. It's this combination of ulcers and inflammation that leads to the symptoms associated with UC, including bloody stool and frequent bowel movements.

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  • Taking DELZICOL
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    IMPORTANT RISK INFORMATION

    Do not take DELZICOL if you are:

    • allergic to salicylates or aminosalicylates, such as aspirin or medications that contain aspirin
    • allergic to any of the ingredients of DELZICOL

    Before taking DELZICOL, tell your doctor if you:

    • Have or have had kidney problems
    • Are allergic to sulfasalazine
    • Have or have had heart-related allergic reactions, such as inflammation of the heart muscle (myocarditis) or inflammation of the lining of the heart (pericarditis)
    • Take any iron-containing supplements
    • Have or have had liver problems
    • Have or have had a stomach blockage
    • Are pregnant, nursing, or are planning to become pregnant or to breastfeed
    • Have any other medical conditions

    Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking DELZICOL with nonsteroidal anti-inflammatory drugs (NSAIDs) may cause kidney problems. Taking DELZICOL with azathioprine or 6-mercaptopurine may cause blood problems. Ask your doctor if you are not sure if you are taking one of these medicines. Your doctor may do certain tests during treatment with DELZICOL.

    What are the possible side effects of DELZICOL?

    DELZICOL may cause serious side effects, including:

    • Kidney problems: Your doctor may check to see how your kidneys are working before taking DELZICOL.
    • Acute Intolerance Syndrome and Other Allergic Reactions: Some people who use DELZICOL can have allergic-type reactions, including acute intolerance syndrome. Other allergic reactions can cause heart problems including an inflammation of the sac around the heart (pericarditis), blood problems, and problems with other organs in the body such as the kidneys, liver and lungs. When this happens, it is usually in people who have had an allergic reaction to sulfasalazine. Stop using DELZICOL and tell your doctor right away if you get any of these symptoms: cramping, stomach (abdominal) pain, bloody diarrhea, fever, headache, chest pain, decrease in the amount of urine, shortness of breath, eye inflammation, fatigue, and rash.
    • Liver Failure: This can happen in people who have a history of liver problems and have taken other medicines that contain mesalamine. Tell your doctor right away if you get any of these symptoms while using DELZICOL: yellowing of your eyes, itchy skin, feeling very tired, flu-like symptoms, nausea or vomiting.
    • Sun Sensitivity: DELZICOL can make your skin sensitive to the sun if you have skin conditions such as atopic dermatitis and atopic eczema. Try to limit your time in the sun. You should use sunscreen and wear a hat and clothes that cover your skin if you have to be in the sunlight.
    • Kidney Stones: Drink plenty of fluids when using DELZICOL to decrease your chance of getting kidney stones. Call your doctor right away if you have any of these symptoms: severe pain in your side or your back, or blood in your urine.

    The most common side effects of DELZICOL include:

    • Adults: belching, stomachache, constipation, dizziness, runny nose, back pain, rash, upset stomach, and flu symptoms.
    • Children (5 to 17 years of age): inflammation of the nose and pharynx, headache, stomachache, dizziness, inflammation of the sinuses, rash, cough, diarrhea, tiredness, fever, and increased lipase.

    Tell your doctor if you have any side effect that bothers you or does not go away. These are not all the possible side effects of DELZICOL.

    What is DELZICOL?

    DELZICOL® (mesalamine) delayed-release capsules is a prescription medication approved for the treatment of mildly to moderately active ulcerative colitis (UC) in patients 5 years of age and older and for the maintenance of remission of UC in adults.

    Please see full Prescribing Information for DELZICOL.

    The product information provided on this site is intended only for residents of the United States. The products discussed on this site may have different product labeling outside of the United States.

    The health information described on this site is provided for educational purposes only and is not intended to substitute for discussions with a healthcare provider.